职称/职务

副教授

研究方向

天然药物化学，有机合成方法学

邮箱

guozheng.huang@ahut.edu.cn;

guozheng.huang@yahoo.com

学习工作经历

2020.09 – 安徽工业大学化学太阳成集团tyc33455cc，副教授；

2016.12 – 2020.08中国科学院新疆理化所，研究员；

2016.07 – 2016.11中国科学院新疆理化所，副研究员；

2015.06 – 2016.06上海师范大学生命与环境科学学院，讲师；

2012.07 – 2015.05德国维尔茨堡大学药物化学与食品化学学院，博士研究生，药物化学专业；

2011.11 – 2012.06德国雷根斯堡大学药学系，博士研究生，药物化学专业；

2004.09 – 2007.07中国科学院研究生院，新疆理化技术研究所，硕士研究生，有机化学专业

主要科研项目及成果

主要围绕天然产物，开展分离纯化，结构改造和药理学研究。代表性工作有：(1)通过对中国传统中药吴茱萸的活性成分——吴茱萸碱的结构修饰，发现了一个丁酰胆碱酯酶抑制剂，并具有神经保护作用；(2)发现了一种简单快速地制备吴茱萸次碱及其类似物的合成方法；(3)在化学上首次实现了从水飞蓟素到次大风子素的有效转化方法，并对水飞蓟素进行衍生化，得到的次大风素类化合物有较好的抗癌和抗炎效果；(4)合作开展了新疆一枝蒿中的特有的倍半萜生物碱——一枝蒿碱G及其相关异构体的全合成；(5)合作开展了药用蕨类植物的活性成分分离，结构改造及活性研究，得到了抗癌活性较好的先导化合物。迄今发表各类科研论文63篇，相关工作发表于Organic Letters，European Journal of Medicinal Chemistry，Phytomedicine，Bioorganic Chemistry，Journal of Molecular Structure，Current Topics in Medicinal Chemistry，ACS Chemical Neuroscience，Bioorganic & Medicinal Chemistry，Journal of Chromatography B，Phytochemistry Letters，Natural Product Research等期刊。申请发明专利17项,其中10项已经获得专利授权。参编图书1部。目前正在开展天然产物的结构改造和药理学研究。主要的研究兴趣包括天然产物的分离、结构修饰及活性研究，有机合成方法学。2016年入选国家级高层次人才引进计划，2020年入选马鞍山市“龙马工程”高层次人才。目前主要的研究包括天然产物的分离、结构修饰及活性研究，新药合成，有机合成方法学。

近5年来主要期刊论文

(详细列表见:https://orcid.org/0000-0002-5730-9549)

1.Ting Gao, Xin Wang, Yan Liu, Yong Wu, Chao Niu*, Jianzu Shen, Zi Liu, Liang Ma, Jianguo Cao*,Guozheng Huang*.Anticancer activity of 4α-(cyclopropylformylpiperazinyl)-4-deoxypodophyllotoxin and its mechanism of action.Journal of Molecular Structure,2024,1311,138460https://doi.org/10.1016/j.molstruc.2024.138460

2.Zi Liu, Chenlu Xia, Nina Wang, Jianguo Cao, Guozheng Nina Wang, Li Qin, Zi Liu, Jianguo Cao, Jiayi Huang, Liang Ma*,Guozheng Huang*. Discovery of a pimaradiene that decreases viability of MDA-MB-468 cells through inhibition of EGFR signaling pathway.Chemistry & Biodiversity,2024,21(4), e202400288.https://doi.org/10.1002/cbdv.202400288

3.Baoxiang Wu,Xian-Yong Wei*, Nina Wang, Chenlu Xia, Rongrong Bao, Jianguo Cao, Zhi-Min Zong, Zi Liu, Liang Ma*,Guozheng Huang*. Synthesis and antiproliferative evaluation of phenylalkylamino-containing alepterolic acid derivatives.Journal of Molecular Structure,2023,1284, 135358https://doi.org/10.1016/j.molstruc.2023.135358

4.Xiaoxiao Pei¹, Zeyi Zhang¹, Nina Wang,Guozheng Huang*, Xiaoran Min, Yanzi Yang *, Jianguo Cao*. Onychiol B attenuates lipopolysaccharide-induced inflammation via MAPK/NF-κB pathways and acute lung injuryin vivo.Bioorganic Chemistry,2023,132, 106351.https://doi.org/10.1016/j.bioorg.2023.106351

5.Tianju Jiang, Xiling Dai, Ting Gao, Lili Wang, Fan Yang, Yu Zhang, Nina Wang,Guozheng Huang*, Jianguo Cao *.Ancepsone A, a new cheilanthane sesterterpene fromAleuritopteris anceps.Tetrahedron Letters,2022,100, 153869.https://doi.org/10.1016/j.tetlet.2022.153869

6.Huanwu Hong, Siyue Lou, Fanli Zheng, Hang Gao, Nina Wang, Shasha Tian,Guozheng Huang*,Huajun Zhao*. Hydnocarpin D attenuates lipopolysaccharide-1 induced acute lung injury via MAPK/NF-κB and Keap1/Nrf2/HO-1 pathway.Phytomedicine,2022, 101,154143.https://doi.org/10.1016/j.phymed.2022.154143

7.Xin Zhang¹, Tingting Yang¹, Xin Jin, Kaige Lin, Xiling Dai, Ting Gao,Guozheng Huang*, Minghui Fan, Liang Ma, Zi Liu*, Jianguo Cao*. Synthesis and biological evaluation of cytotoxic activity of novel podophyllotoxin derivatives incorporating piperazinyl-cinnamic amide moieties.Bioorganic Chemistry,2022,123,105761.https://doi.org/10.1016/j.bioorg.2022.105761

8.Liang Ma, Xiaojing Xuan, Minghui Fan, Yumeng Zhang, Guozan Yuan,Guozheng Huang, Zi Liu*. A novel 8-hydroxyquinoline derivative induces breast cancer cell death through paraptosis and apoptosis.Apoptosis,2022,27, 577–589.https://doi.org/10.1007/s10495-022-01737-w

9.Junping Chen, Xiling Dai, Can Jiang, Yuxi Fu, Tianju Jiang, Liping Tang, Linrui Wang, Quanxi Wang,Guozheng Huang*, Jianguo Cao*.One new protocatechuic acid methyl ester and one pair of enantiomeric dihydroflavones isolated fromPhymatopteris hastata.Phytochemistry Letters,2021,43, 130-134.https://doi.org/10.1016/j.phytol.2021.03.025

10.Siyue Lou, Huanwu Hong, Liwaliding Maihesuti, Hang Gao, Zhihui Zhu, Lili Xu, Shasha Tian, Guoyin Kai,Guozheng Huang*,Huajun Zhao*. Inhibitory effect of hydnocarpin D on T cell acute lymphoblastic leukemia via induction of ferroptosis-conjugated autophagy.Experimental Biology and Medicine,2021,246(13),1541-1553.https://doi.org/10.1177/15353702211004870

11.Liwaliding Maihesuti, Hongwei Gao, Qi Wang, Jianguo Cao, Haji Akber Aisa*,Guozheng Huang*. Structural modification of sylibin to derivatives of sylibin/hydnocarpin D/silandrin, and biological evaluation of their anticancer activities.Current Topics in Medicinal Chemistry,2021,21(15), 1398-1417.https://doi.org/10.2174/1568026621666210701142826

12.Can Jiang, Junping Chen, Xiling Dai, Qi Wang, Jianguo Cao*,Guozheng Huang*.ent-Pimaradiene and cyathane diterpenes fromAleuritopteris albofusca.Phytochemistry Letters,2020,40, 10–14.https://doi.org/10.1016/j.phytol.2020.09.008

13.Ying Li, Wendian Li, Jiangyan Tian,Guozheng Huang*, Hui Lv*. Nickel-catalyzed asymmetric addition of aromatic halides to ketones: highly enantioselective synthesis of chiral 2,3-dihydrobenzofurans containing a tertiary alcohol.Organic Letters,2020, 22(14), 5553–5557.https://dx.doi.org/10.1021/acs.orglett.0c01612

14.Sheng Zhang, Niping Feng, Jinwen Huang, Minglong Wang, Lei Zhang, Junjie Yu, Xiling Dai, Jianguo Cao*,Guozheng Huang*. Incorporation of amino moiety to alepterolic acid improve activity against cancer cell lines: synthesis and biological evaluation.Bioorganic Chemistry,2020, 98, 103756.https://doi.org/10.1016/j.bioorg.2020.103756

15.XiaoyanLiu,JianguoCao,Guozheng Huang*,QingjieZhao*,JingshanShen.Biologicalactivitiesofartemisinin derivatives beyond malaria.Current Topics in Medicinal Chemistry,2019, 19(3), 205–222.https://doi.org/10.2174/1568026619666190122144217

参编图书

16.Chapter 7 “Anti-cancer hybrids”. Qingjie Zhao,Guozheng Huang*, in the book “Design of Hybrid Molecules for Drug Development”, edited by Michael Decker, published by Elsevier. 2017. ISBN: 978-0-08-101011-2.http://doi.org/10.1016/B978-0-08-101011-2.00007-6